Formaldehyde → HCID 86747327, compound

HRID 1656919Notes

Reaction equation

HRID 1656919 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:13][CH2:12][NH:11][C:10]2=[CH:14][N+:15]([O-:17])=[O:16])=[CH:4][CH:3]=1.[CH2:18]=O.[CH2:20]([SH:23])[CH:21]=[CH2:22]>C(O)C>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:13][CH2:12][NH:11][C:10]2=[C:14]([N+:15]([O-:17])=[O:16])[CH2:18][S:23][CH2:20][CH:21]=[CH2:22])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 13367Allyl MercaptanHCID 1809572-Chloro-5-{[2-(nitromethylidene)imidazolidin-1-yl]methyl}pyridine

Product 1

HCID 86747327HCID 86747327, compoundYield 49.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

0.5 g of 1-(6-chloro-3-pyridylmethyl)-2-nitromethyleneimidazolidine, 0.19 g of 37% formaldehyde aqueous solution and 0.22 g of allylmercaptan were added to 10 ml of ethanol, and were reacted under reflux for 2 hours. After completing the reaction, ethanol was distilled off under reduced pressure, and a small amount of ethyl acetate was added to the residue thus obtained to filter the insoluble materials out, thus obtaining 0.33 g of the aimed product (Compound No. 3) having a melting point of from 134.0° to 135.0° C.

Workup

  1. customwere reacted
  2. temperatureunder reflux for 2 hours
  3. distillationwas distilled off under reduced pressure
  4. additiona small amount of ethyl acetate was added to the residue
  5. customthus obtained
  6. filtrationto filter the insoluble materials out,

Sources & evidence

ORD record
ord-fa8e9442f0ab4c23982c08c8c5191859
Source dataset
uspto-grants-1993_10
Patent number
US05256674

Reaction notes

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