反应详情

0.5 g of 1-(6-chloro-3-pyridylmethyl)-2-nitromethyleneimidazolidine, 0.18 g of 37% formaldehyde aqueous solution and 0.24 g of mercaptomethyl trimethylsilane were added to 15 ml of ethanol, and were reacted under reflux for 1 hour. After completing the reaction, the reaction liquor was cooled by ice to precipitate a crystal. The crystal thus precipitated was taken out by filtration, and was washed with a cold ethanol to obtain 0.3 g of the aimed product (Compound No. 20) having a melting point of from 162.3° to 164.3° C.

1. customwere reacted
2. temperatureunder reflux for 1 hour
3. customthe reaction
4. temperaturethe reaction liquor was cooled by ice
5. customto precipitate a crystal
6. customThe crystal thus precipitated
7. filtrationwas taken out by filtration
8. washwas washed with a cold ethanol