Potassium Carbonate → HCID 15729160, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-acetylamino-5-chlorothiazole (5.3 g), 1-methyl-2-mercaptoimidazole (3.6 g) and potassium carbonate (6.2 g) in N,N-dimethylformamide (50 ml) was heated at 130° C. for 5.5 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was triturated with water. The precipitates were collected by filtration washed with water and dried in vacuo to give 2-acetylamino-5-(1-methylimidazol-2-ylthio)thiazole (6.95 g, yield: 91.2%). mp: 155°-160° C. (dec.) IR (Nujol): 3400, 1690, 1565, 1300 cm-1

Provenance & Evidence