HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Acetylamino-5-(4-hydroxyphenylthio)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Mercaptophenol | HCID 240147 | — |
| Reactant | 2-Acetamido-5-chlorothiazole | HCID 4684134 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Acetylamino-5-(4-hydroxyphenylthio)thiazole | HCID 15729180 | 56.6% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 2-acetylamino-5-chlorothiazole (1.76 g), 4-hydroxythiophenol (1.3 g) and potassium carbonate (2 g) in N,N-dimethylformamide (30 ml) was heated at 120° C. for 2.5 hours with stirring. The reaction mixture was poured into ice water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-acetylamino-5-(4-hydroxyphenylthio)thiazole (1.5 g, yield: 56.6%). mp: 265°-267° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05256675 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-e212e19cbcd94aa2a1b039fd2b68ef12 |
| Source note | uspto-grants-1993_10 |