Diethylene Glycol Monoethyl Ether → HCID 13520603, compound

Participants

Reaction Steps

A mixture of 35.5 g of 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-5-cyanoindole [m.p. 167°; obtainable from the corresponding 5-formyl compound via the oxime], 27.1 g of NaOH, 520 ml of water and 420 ml of diethylene glycol monoethyl ether is stirred for 3 hours at a bath temperature of 140°. The mixture is cooled and worked up in the customary manner to give 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-indole-5-carboxamide, m.p. 200°-205°.

Provenance & Evidence