Pyridinium chloride → HCID 57094023, compound

HRID 1657012Notes

Reaction equation

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]([OH:30])=[O:29])[CH:26]=4)[NH:21][CH:20]=3)[CH2:13][CH:14]=2)=[CH:5][CH:4]=1.Cl.N1C=CC=CC=1>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]([OH:30])=[O:29])[CH:26]=4)[NH:21][CH:20]=3)[CH2:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 57111772HCID 57111772, compound

Product 1

HCID 57094023HCID 57094023, compound

Procedure

A mixture of 4.04 g of 3-[4-(4-p-methoxyphenyl-1,2,3,6-tetrahydropyridyl)-butyl]-indole-5-carboxylic acid and 3.5 g of pyridine hydrochloride is stirred for 3 hours at 160°. Working up in the customary manner gives 3-[4-(4-p-hydroxyphenyl-1,2,3,6-tetrahydropyridyl)-butyl]-indole-5-carboxylic acid.

Sources & evidence

ORD record: ord-1c2289fe3b9248b88291ca3ad79cc389
Source dataset: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05256673

Reaction notes

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