Diethyl Ether → HCID 13520608, compound

Participants

Reaction Steps

36 g of 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-5-hydroxymethylindole are dissolved in 1.6 liters of THF, and 300 ml of ether are added. 55 g of MnO2 are added with stirring. The mixture is stirred for 16 hours at 20°, a further 100 g of MnO2 are added in portions, and stirring is continued for a further 100 hours at 20°. Filtration and working up in the customary manner gives 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-5-formylindole, m.p. 131°.

Provenance & Evidence