Potassium Hydroxide → HCID 13520618, compound

HRID 1657020Notes

Reaction equation

HRID 1657020 reaction equation
[C:1]1([C:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][S:15][CH2:16][C:17]3[C:25]4[C:20](=[CH:21][C:22]([C:28]([O:30]CC)=[O:29])=[C:23]([O:26][CH3:27])[CH:24]=4)[NH:19][CH:18]=3)[CH2:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>O>[C:1]1([C:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][S:15][CH2:16][C:17]3[C:25]4[C:20](=[CH:21][C:22]([C:28]([OH:30])=[O:29])=[C:23]([O:26][CH3:27])[CH:24]=4)[NH:19][CH:18]=3)[CH2:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13520613HCID 13520613, compound

Product 1

HCID 13520618HCID 13520618, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.5 g of 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-2-thiabutyl]-5-methoxy-6-ethoxycarbonylindole are boiled with 20 ml of water and 100 ml of 2N ethanolic KOH for 30 minutes, and the mixture is worked up in the customary manner to give 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)-2-thiabutyl]-5-methoxyindole-6-carboxylic acid, m.p. 168°-171°.

Sources & evidence

ORD record
ord-2a49e8a4d0824a469d9704b96c980ef0
Source dataset
uspto-grants-1993_10
Patent number
US05256673

Reaction notes

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