Hydrochloric Acid → HCID 19786949, compound

Participants

Reaction Conditions

Reaction Steps

4.13 g of 5-methyl-1-(3-phenoxyphenyl)-imidazole-4-carbonitrile is dissolved in 200 ml of toluene. At -60° C. to -70° C., 15 ml of Dibah, 1.2 mol in toluene is instilled. It is stirred for 2 hours at -70° C., 2.5 ml of water is instilled at -70° C. and the mixture is allowed to come to room temperature. It is adjusted to pH 4 with 2N hydrochloric acid solution and the mixture is extracted with toluene and ethyl acetate. The organic phases are combined and dried on MgSO4. After purification by column chromatography, 2.46 g (59% of theory) of the title compound is obtained as oil.

Provenance & Evidence