HCID 18949816, compound → HCID 135786535, compound

HRID 1657078Notes

Reaction equation

HRID 1657078 reaction equation
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([C:22]2[O:26][N:25]=[C:24]([Br:27])[N:23]=2)[CH:8]=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[C:10]=1[O:11]COCCOC)([CH3:4])[CH3:3]>[Br-].[Zn+2].[Br-]>[Br:27][C:24]1[N:23]=[C:22]([C:7]2[CH:6]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[C:10]([OH:11])=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:8]=2)[O:26][N:25]=1

Participants

3

Reactant 1

HCID 18949816HCID 18949816, compound

Product 1

HCID 135786535HCID 135786535, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 10421208Zinc bromideCatalyst

Procedure

In a manner analogous to Example 59, 0.8 g (0.002 mole) of 5-[3,5-bis(1,1-dimethylethyl)-4-[(2-methoxyethoxy)methoxy]phenyl]-3-bromo-1,2,4-oxadiazole is reacted with 2.0 g (0.009 mole) of zinc bromide to give 0.4 g (65%) of 4-(3-bromo-1,2,4-oxadiazol-5-yl)-2,6-bis(1,1-dimethylethyl)phenol, mp 113°-115° C.

Sources & evidence

ORD record
ord-0c3581413ce041798a38b390a6e200f6
Source dataset
uspto-grants-1993_10
Patent number
US05256680

Reaction notes

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