HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1657155Generated: October 25, 2026
Dimethylamine → 2-Dimethylamino-4'-difluoromethoxyacetophenone
https://huagongshe.com/reaction/1657155
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 2-Bromo-1-(4-(difluoromethoxy)phenyl)ethan-1-one | HCID 703496 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Dimethylamino-4'-difluoromethoxyacetophenone | HCID 18980927 | 44.4% |
Reaction Steps
To 7.5 g (165 mmole) of anhydrous dimethylamine in 50 ml of methylene chloride and cooled to -30° C. was added a solution of 20 g (664 mmole) of 2-bromo-4'-difluoromethoxyacetophenone in 50 ml of methylene chloride. After the addition was complete the reaction was allowed to warm to 20° C. Concentration in vacuo, partitioning between diethyl ether and 1M aqueous sodium hydroxide, washing with brine, drying over anhydrous magnesium sulfate, and reconcentration in vacuo yielded 16.8 g of 2-dimethylamino-4'-difluoromethoxyacetophenone, an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05256670 |
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| Source dataset | uspto-grants-1993_10 |
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| ORD ID | ord-bf0d2813d21f486291937ab9fe6f26e7 |
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| Source note | uspto-grants-1993_10 |
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