HCID 19786504, compound → HCID 19786507, compound

Participants

Reaction Steps

By substantially following the procedure given in Example 19i using 1.0 g (2.2 mmole) of N-(4-trifluoromethylphenyl)-3-(4-difluoromethoxy-3-methylphenyl)-4-propylamino-4,5-dihydro-1H-pyrazole-1-carboxamide (Example 29b) and 10 ml of 1.0M diisobutylaluminum hydride one obtains 0.6 g of N-(4-trifluoromethylphenyl)-3-(4-difluoromethoxy-3-methylphenyl)-4-propylamino-2,3,4,5-tetrahydro-1H-pyrazole-1-carboxamide, an oil. NMR 0.9 t 3H, 2.5 m 2H, 2.3 s 3H, 2.6 t 2H, 3.5 bd 2H, 3.7 m 1H, 4.0 m 2H, 4.8 bm 1H, 6.4 t 1H, 7.1 m 3H, 7.4 m 4H, 8.3 s 1H.

Provenance & Evidence