Toluene → 5-[4'-(2"-Hydroxyethyl)piperazino]benzylidene-3-aminorhodanine

HRID 1657179Notes

Reaction equation

HRID 1657179 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:17]=[CH:16][C:13](C=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1.[NH2:18][N:19]1[C:23](=[O:24])[CH2:22][S:21][C:20]1=[S:25].[C:26]1(C)C=CC=CC=1>C(O)(=O)C>[OH:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:11]=[CH:12][CH:13]=[C:16]([CH:17]=2)[CH:26]=[C:22]2[S:21][C:20](=[S:25])[N:19]([NH2:18])[C:23]2=[O:24])[CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 1140TolueneHCID 740333-AminorhodanineHCID 435921624-[4'-(2"-Hydroxyethyl)piperazino]benzaldehyde

Product 1

HCID 544465515-[4'-(2"-Hydroxyethyl)piperazino]benzylidene-3-aminorhodanine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

An admixture of 4.7 grams of 4-[4'-(2"-hydroxyethyl)piperazino]benzaldehyde (0.02 mol), 3.0 grams of 3-aminorhodanine (0.02 mol), toluene (30 mL), and glacial acetic acid (5 mL) was refluxed for 4 hours. The admixture was then cooled to room temperature and the solvent was decanted. The remaining paste was triturated with ethanol and then filtered off and dried.

Workup

  1. customthe solvent was decanted
  2. customThe remaining paste was triturated with ethanol
  3. filtrationfiltered off
  4. customdried

Sources & evidence

ORD record
ord-7f9f30bb405c4d4fb68122ee8ee02dc1
Source dataset
uspto-grants-1993_10
Patent number
US05256784

Reaction notes

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