HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 3-(2-Chlorobenzoyl)-2-(2-nitroethenylamino)-5-ethylthiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Morpholine, 4-(2-nitroethenyl)- | HCID 683970 | — |
| Reactant | (2-Amino-5-ethylthiophen-3-yl)(2-chlorophenyl)methanone | HCID 13163365 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2-Chlorobenzoyl)-2-(2-nitroethenylamino)-5-ethylthiophene | HCID 67757398 | 84.1% |
Reaction Steps
A mixture of 2-amino-3-(2-chlorobenzoyl)-5-ethylthiophene (5.30 g), 1-morpholino-2-nitroethene (3.16 g), 6N HCl (5 ml) and acetone (25 ml) was stirred at room temperature for one hour. Water was added to the mixture, which was extracted with ethene acetate. The extract was washed with water and dried over MgSO4, and then the solvent was distilled off to obtain 3-(2-chlorobenzoyl)-2-(2-nitroethenylamino)-5-ethylthiophene as crystals (5.65 g, 84.1%). The crystals were recrystallized from acetone to obtain yellow plates, mp: 125°-126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05256782 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-cf6260d2376e4a2f9682a1bf93b9c72e |
| Source note | uspto-grants-1993_10 |