Hydrogen Sulfide → Methyl p-[2-(p-amidinobenzamido)ethyl]phenoxyacetate

HRID 1657236Notes

Reaction equation

HRID 1657236 reaction equation
S.[C:2]([C:4]1[CH:26]=[CH:25][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:24]=[CH:23][C:16]([O:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=2)=[O:9])=[CH:6][CH:5]=1)#[N:3].[N:27]1C=CC=CC=1.C(N(CC)CC)C>>[C:2]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:24]=[CH:23][C:16]([O:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=2)=[O:9])=[CH:25][CH:26]=1)(=[NH:27])[NH2:3]

Participants

4

Reactant 3

HCID 402Hydrogen SulfideHCID 10315069Methyl 4-[2-(p-cyanobenzamido)ethyl]phenoxyacetateHCID 22561186Pyridine triethylamine

Product 1

HCID 10360837Methyl p-[2-(p-amidinobenzamido)ethyl]phenoxyacetate

Procedure

H2S was passed for 45 minutes through a suspension of 2.0 g of methyl 4-[2-(p-cyanobenzamido)ethyl]phenoxyacetate in 24 ml of pyridine/triethylamine (7:1) at 0° C. The solution resulting after 12 hours was concentrated, and a suspension was made of the residue in methanol and filtered. The residue on the filter was immediately suspended in 30 ml of acetone, and 4 ml of methyl iodide were added. After 2.5 hours the precipitate was filtered off, washed with a little is acetone and, after drying, dissolved in 20 ml of methanol. 2.0 g of ammonium acetate were added and the mixture was then left to react at room temperature for 2 hours, during which a colorless precipitate formed, and this was filtered off and reprecipitated from methanol. Methyl p-[2-(p-amidinobenzamido)ethyl]phenoxyacetate was obtained as the acetate salt, melting point above 200° C., after drying under high vacuum.

Workup

  1. customThe solution resulting after 12 hours
  2. concentrationwas concentrated
  3. filtrationfiltered
  4. addition4 ml of methyl iodide were added
  5. filtrationAfter 2.5 hours the precipitate was filtered off
  6. washwashed with
  7. customafter drying
  8. dissolutiondissolved in 20 ml of methanol
  9. addition2.0 g of ammonium acetate were added
  10. waitthe mixture was then left
  11. customto react at room temperature for 2 hours, during which a colorless precipitate
  12. customformed
  13. filtrationthis was filtered off
  14. customreprecipitated from methanol

Sources & evidence

ORD record
ord-5dea3f0ee6eb4dac9695d776cd23bf95
Source dataset
uspto-grants-1993_10
Patent number
US05256812

Reaction notes

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