HCID 54323449, compound → Acetate

HRID 1657243Notes

Reaction equation

HRID 1657243 reaction equation
[C:1]([C:4]1[CH:27]=[CH:26][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[CH:25]=[CH:24][C:16]([CH:17]([CH3:23])[CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=2)=[O:9])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2]>CO.[Pd]>[CH3:22][O:21][C:19](=[O:20])/[CH:18]=[C:17](\[CH3:23])/[C:16]1[CH:15]=[CH:14][C:13]([CH2:12][CH2:11][NH:10][C:8](=[O:9])[C:7]2[CH:6]=[CH:5][C:4]([C:1](=[NH:2])[NH2:3])=[CH:27][CH:26]=2)=[CH:25][CH:24]=1.[C:19]([O-:21])(=[O:20])[CH3:18]

Participants

5

Reactant 1

HCID 54323449HCID 54323449, compound

Product 2

HCID 175AcetateHCID 67854816HCID 67854816, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

From 190 mg of methyl,(E)-p-[2-(p-amidinobenzamido)ethyl]-β-methylcinnamate there were obtained after hydrogenation in methanol in the presence of 10% Pd/C under atmospheric pressure at room temperature after 24 hours 113 mg of crystalline acetate of methyl rac-p-[2-(p-amidinobenzamido) ethyl]-β-methyl-hydrocinnamate.

Sources & evidence

ORD record
ord-9f1f0a69b2b24669a7c7b73bd5fcb035
Source dataset
uspto-grants-1993_10
Patent number
US05256812

Reaction notes

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