Hydrochloric Acid → HCID 10333880, compound

Participants

Reaction Steps

A solution of allyl 2,2-bis(p-tolyl)acetate (8.00 g) in toluene (40 ml) was added dropwise to a suspension of sodium hydride (60% dispersion in mineral oil) (1.6 g) in toluene (30 ml) at 130° C. under nitrogen atmosphere, and the mixture was refluxed for 6 hours. After being cooled, the mixture was poured into cooled 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to give 2,2-bis(p-tolyl)-4-pentenoic acid (4.41 g). It was used for the next reaction without further purification.

Provenance & Evidence