HCID 10039421, compound → HCID 9990821, compound

HRID 1657308Notes

Reaction equation

HRID 1657308 reaction equation
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]=1[CH2:12][CH2:13][NH:14][C:15](N1C=CN=C1)=[O:16])[CH3:2]>C1(C)C=CC=CC=1>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[C:15](=[O:16])[NH:14][CH2:13][CH2:12][C:4]=12)[CH3:2]

Participants

3

Reactant 1

HCID 10039421HCID 10039421, compound

Product 1

HCID 9990821HCID 9990821, compoundYield 9%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of N-[2-(3-ethylindol-2-yl)ethyl]-1-imidazolecarboxamide (2.2 g) in toluene (50 ml) was refluxed for 3 hours. After the mixture was evaporated in vacuo, the residue was purified by silica gel column chromatography (5% methanol-chloroform) to give 5-ethyl-3,4-dihydropyrimido[1,6-a]indol-1(2H)-one (0.15 g).

Workup

  1. customAfter the mixture was evaporated in vacuo
  2. customthe residue was purified by silica gel column chromatography (5% methanol-chloroform)

Sources & evidence

ORD record
ord-b878a263453f4ffabb2d14665081acb3
Source dataset
uspto-grants-1993_10
Patent number
US05256780

Reaction notes

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