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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1657374Generated: November 1, 2026

Carbon Dioxide → 5-(Dimethylamino)-alpha-phenyl-1,2,4-oxadiazole-3-acetic acid

https://huagongshe.com/reaction/1657374

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbon DioxideHCID 280—
ReactantDimethylamino-3-(phenylmethyl)-1,2,4-oxadiazoleHCID 15613847—
ReactantButyllithiumHCID 178418339—
Product5-(Dimethylamino)-alpha-phenyl-1,2,4-oxadiazole-3-acetic acidHCID 21533226—

Reaction Steps

5-(Dimethylamino-3-(phenylmethyl)-1,2,4-oxadiazole from part (a) is treated with a solution of butyl lithium and carbon dioxide according to the procedure of Example 1 (b) to yield 5-(dimethylamino)-α-phenyl-1,2,4-oxadiazole-3-acetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03960849
Source datasetuspto-grants-1976_06
ORD IDord-8bfd3efec7ad4278a3820216acd3f8fa
Source noteuspto-grants-1976_06