Chlorosulfonic acid → HCID 178527422, compound

HRID 1657377Notes

Reaction equation

HRID 1657377 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[C:4]([S:15](=[O:18])(=[O:17])N)=[CH:5][C:6]2[S:11](=[O:13])(=[O:12])[NH:10][CH:9]=[N:8][C:7]=2[CH:14]=1.[Cl:21]S(O)(=O)=O>O>[F:1][C:2]([F:20])([F:19])[C:3]1[C:4]([S:15]([Cl:21])(=[O:18])=[O:17])=[CH:5][C:6]2[S:11](=[O:13])(=[O:12])[NH:10][CH:9]=[N:8][C:7]=2[CH:14]=1

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 178514675HCID 178514675, compound

Product 1

HCID 178527422HCID 178527422, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6-Trifluoromethyl-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide (0.2 mole) is added portionwise with stirring to chlorosulfonic acid (300 ml.) cooled in an ice-bath over 30 minutes. The mixture is then heated for 2 hours on the steam bath, cooled and poured onto a mixture of ice and water. The solid is collected on the filter, washed with cold water and air-dried at room temperature and recrystallized from acetone-hexane.

Workup

  1. temperaturecooled in an ice-bath over 30 minutes
  2. temperatureThe mixture is then heated for 2 hours on the steam bath
  3. temperaturecooled
  4. customThe solid is collected on the filter
  5. washwashed with cold water
  6. customair-dried at room temperature
  7. customrecrystallized from acetone-hexane

Sources & evidence

ORD record
ord-47e056598d5444ce82a9b51115e0f3fd
Source dataset
uspto-grants-1976_06
Patent number
US03960854

Reaction notes

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