2H-1,2,4-benzothiadiazine → HCID 21533315, compound

HRID 1657382Notes

Reaction equation

HRID 1657382 reaction equation
S1C2C=CC=CC=2N=CN1.[Cl:11][C:12]1[C:13]([S:24][CH:25]([CH2:28][CH3:29])[CH2:26][CH3:27])=[CH:14][C:15]2[S:20](=[O:22])(=[O:21])[NH:19]C=[N:17][C:16]=2[CH:23]=1>>[S:20]([C:15]1[CH:14]=[C:13]([S:24][CH:25]([CH2:28][CH3:29])[CH2:26][CH3:27])[C:12]([Cl:11])=[CH:23][C:16]=1[NH2:17])(=[O:21])(=[O:22])[NH2:19]

Participants

3

Reactant 2

HCID 4733682H-1,2,4-benzothiadiazineHCID 178447688HCID 178447688, compound

Product 1

HCID 21533315HCID 21533315, compound

Procedure

By replacing the 1,2,4-benzothiadiazine derivative employed in Step A-1 by an equivalent quantity of 6-chloro-7-(1-ethylpropylthio)-1,2,4-benzothiadiazine-1,1-dioxide (prepared as described in Example 7) and following substantially the same procedure described in Step A-1, there is obtained 2-sulfamoyl-4-(1-ethylpropylthio)-5-chloroaniline, m.p. 118°-120° C.

Sources & evidence

ORD record
ord-f2b6a3d63d9f47c38ba9e43a4fc6e5bf
Source dataset
uspto-grants-1976_06
Patent number
US03960854

Reaction notes

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