反应详情

A mixture of 2.4 g of 3-(2-chloroethyl)-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed for 30 hours. After completion of the reaction, the rection mixture was then treated in the same manner as in Example 4, and the obtained crude crystals were recrystallized from a mixture of methanol and ethanol to give 2.2 g of the desired compound as pale yellow plates, m.p. 272° - 274°C (decomp.).

1. temperaturewas refluxed for 30 hours
2. customAfter completion of the reaction
3. additionthe rection mixture was then treated in the same manner as in Example 4
4. customthe obtained crude crystals
5. customwere recrystallized from a mixture of methanol and ethanol