反应详情

A mixture of 1.3 g of 2-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one, 2.1 g of 1-(m-tolyl)piperazine and 20 ml of toluene was refluxed for 30 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The obtained residue was purified by means of column chromatography using alumina and recrystallized from a mixture of ethanol and n-hexane to give 0.8 g of the desired compound as pale yellow scales, m.p. 119° - 120°C.

1. temperaturewas refluxed for 30 hours
2. customAfter completion of the reaction
3. filtrationthe reaction mixture was filtered
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe obtained residue was purified by means of column chromatography
6. customrecrystallized from a mixture of ethanol and n-hexane