反应详情

A mixture of 1.3 g of 2-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one, 4.2 g of 1-(m-chlorophenyl)piperazine and 20 ml of toluene was refluxed with heating for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 8. The crude crystals thus obtained were recrystallized from ethanol to give 0.5 g of the desired compound as pale orangeyellow needles, m.p. 152° - 154°C.

1. temperaturewas refluxed
2. temperaturewith heating for 30 hours
3. customAfter completion of the reaction
4. additionthe reaction mixture was then treated in the same manner as in Example 8
5. customThe crude crystals thus obtained
6. customwere recrystallized from ethanol