1-(3-Chlorophenyl)piperazine → HCID 12414814, compound

HRID 1657410Notes

Reaction equation

HRID 1657410 reaction equation
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 124149363-(2-Chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

Product 1

HCID 12414814HCID 12414814, compoundYield 40.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2.2 g of 3-(2-chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 4.5 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 10. The crude crystals thus obtained were recrystallized from a mixture of ethanol and n-hexane to give 1.5 g of the desired compound as pale yellow powders, m.p. 127° - 128°C.

Workup

  1. temperaturewas refluxed for 30 hours
  2. customAfter completion of the reaction
  3. additionthe reaction mixture was then treated in the same manner as in Example 10
  4. customThe crude crystals thus obtained
  5. customwere recrystallized from a mixture of ethanol and n-hexane

Sources & evidence

ORD record
ord-10bcdedee62d4034959f8c27fc37583e
Source dataset
uspto-grants-1976_06
Patent number
US03960863

Reaction notes

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