Hydrochloric Acid → HCID 178524709, compound

Participants

Reaction Steps

A solution of 11 g of 3-carboethoxy-4-hydroxy- 6-cyclohexyl-quinoline in 300 ml of ethanol and 50 ml of 10 N sodium hydroxide solution is heated for 3 hours on a water bath. It is then diluted with 200 ml of water and the clear solution is acidified with concentrated hydrochloric acid, whereupon a solid precipitate results. This is filtered off and recrystallised from ethanol or dimethylformamide, and gives 4-hydroxy-6-cyclohexyl-quinoline-3-carboxylic acid in the form of pale yellow crystals of melting point 263°-265°C.

Provenance & Evidence