HCID 178469488, compound → HCID 178524702, compound

Participants

Reaction Steps

A suspension of 15 g of 3-carboethoxy-4-hydroxy-7-cyclohexyl-quinoline in 150 ml of ethanol and 150 ml of 2 N sodium hydroxide solution is boiled under reflux for 7 hours. It is then evaporated to dryness, the residue is dissolved in ethanol-water and the solution is adjusted to pH value 7 with 2 N hydrochloric acid. The crystalline residue thereby produced is filtered off and thoroughly washed with water. 4-Hydroxy-7-cyclohexylquinoline-3-carboxylic acid thus obtained, melts at 241°-243°C (evolution of gas).

Provenance & Evidence