Sodium Hydroxide → HCID 21533366, compound

Participants

Reaction Steps

A suspension of 18.7 g of 1-ethyl-4-oxo-6-methoxy-7-cyclohexyl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester described in Example 18, in 150 ml of ethanol and 150 ml of 2 N sodium hydroxide solution is boiled for 5 hours under reflux. The clear solution thereby produced is evaporated to dryness in vacuo. 2 N Hydrochloric acid is added to the residue. The resulting crystals are filtered off and well washed with water. 1-Ethyl-4-oxo-6-methoxy-7-cyclohexyl-1,4-dihydro-quinoline-3-carboxylic acid, thus obtained, melts at 176°-178°C.

Provenance & Evidence