HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 68142511, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | (1R,3aS,3bS,7S,9aR,9bS,11aR)‐5‐[(Diethylamino)methyl]‐9a,11a‐dimethyl‐1‐[(2R)‐6‐ methylheptan‐2‐yl]‐ 1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH‐cyclopenta[a]phenanthren‐7‐ol | HCID 191548 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68142511 | HCID 68142511 | — |
Reaction Steps
To a solution of 10 parts of 6-(diethylaminomethyl)cholest-5-en-3β-ol in 40 parts of pyridine at 0° is added, slowly and with stirring, 5 parts of propionyl chloride. When the addition is complete, stirring is continued for 2 hours while the reaction mixture warms to room temperature, whereupon 100 parts of water and 100 parts of aqueous 5% potassium bicarbonate are consecutively mixed in. The oil which separates is extracted with hexane. The extract is washed with water, dried over anhydrous sodium sulfate, and stripped of solvent by vacuum distillation, affording 6-(diethylaminomethyl)-3β-(propionyloxy)cholest-5-ene as the residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03960904 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-400ce63836d14681b6213510c204913a |
| Source note | uspto-grants-1976_06 |