反应详情

6-Oxo-6-phenylhexanoic acid (10.3g; 50 mmole), thionyl chloride (25 ml) and dry benzene (150 ml) were heated under reflux for 3 hours. The reagent and solvent were removed on the rotary evaporator. A further 100 ml of benzene was added and the solution again evaporated under reduced pressure (to remove last traces of thionyl chloride). The quantitatively formed, analytically pure brown solid (mp 53°-6°) was used directly in the Friedel-Crafts acylation of step (b).

1. temperatureunder reflux for 3 hours
2. customThe reagent and solvent were removed on the rotary evaporator
3. additionA further 100 ml of benzene was added
4. customthe solution again evaporated under reduced pressure (to remove last traces of thionyl chloride)
5. customThe quantitatively formed