Water → 3-Benzoyl-2-ferrocenylcyclohexene

Participants

Reaction Steps

7-Oxo-7-phenylheptanoylferrocene (1.94g; 5 mmole) was dissolved in 5% H2SO4 /acetic acid (40 ml; excess) at room temperature. The solution was stirred overnight and then poured into water (400 ml) and extracted with chloroform (3 × 200 ml). The organic layers were extracted with water, saturated aqueous sodium bicarbonate, and water, and dried (Na2SO4) to yield a brown oil. The crude product was suspended in hot petroleum ether (bp 40°-60°C) and filtered. The filtrate was submitted to preparative thin layer chromatography on silica. The main yellow band was eluted with petroleum ether/ethyl acetate (10:1) and gave 670 mg (36.2%) of pure 3-benzoyl-2-ferrocenylcyclohexene mp 127°-9°C.

Provenance & Evidence