Isopropylamine → HCID 178464566, compound

HRID 1657527Notes

Reaction equation

HRID 1657527 reaction equation
[IH:1].CS[C:4](=[N:8][C:9](=[NH:11])[NH2:10])[NH:5][CH2:6][CH3:7].[CH:12]([NH2:15])([CH3:14])[CH3:13]>O>[IH:1].[CH2:6]([NH:5][C:4]([NH:8][C:9]([NH2:10])=[NH:11])=[N:15][CH:12]([CH3:14])[CH3:13])[CH3:7]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 178464593HCID 178464593, compound

Product 1

HCID 178464566HCID 178464566, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.2 g. (30 mmol) of 2-methyl-1-ethyl-3-guanyl isothiourea hydroiodide is agitated with 30 ml. of water and 11.8 g. (200 mmol) of isopropylamine for 48 hours at 30° C. and then for 2 hours at the boiling temperature. Excess isopropylamine, methyl mercaptan, and water are removed. To the oily residue, 2 ml. of concentrated aqueous sodium iodide solution and then water are added until a clear solution is obtained. The product is crystallized during standing in a refrigerator and is recrystallized from acetone-petroleum ether.

Workup

  1. customExcess isopropylamine, methyl mercaptan, and water are removed
  2. additionof concentrated aqueous sodium iodide solution and then water are added until a clear solution
  3. customis obtained
  4. customThe product is crystallized
  5. customis recrystallized from acetone-petroleum ether

Sources & evidence

ORD record
ord-147d2f16a8f6456396d558bc94919d42
Source dataset
uspto-grants-1976_06
Patent number
US03960949

Reaction notes

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