Methyl vinyl ketone → Piperitenone

Participants

Reaction Steps

70 g of methyl vinyl ketone are added dropwise in the course of 60 minutes, whilst stirring, to 1,000 g of mesityl oxide and 50 ml of 50% potassium hydroxide solution, at 70°C. Thereafter the mixture is stirred for a further 10 minutes at 70°C and neutralized with glacial acetic acid, and the organic phase is distilled. 181 g of crude piperitenone are obtained; piperitenone content 55.7%, yield therefore 67.2%.

Provenance & Evidence