反应详情

A solution of 0.065 mole of 4-(p-fluorophenyl)-3-cyclohexen-1-one (obtained as in Example 7) and 6 g. of sodium borohydride in 130 ml. of ethanol is stirred at room temperature for about 5 hours. The bulk of the solvent is removed on a rotary evaporator and the residue diluted with water. The precipitated solid is collected on a filter and recrystallized from Skellysolve B to give a 96% yield of 4-(p-fluorophenyl)-3-cyclohexen-1-ol having a melting point of 73° to 74.5° C.

1. customThe bulk of the solvent is removed on a rotary evaporator
2. additionthe residue diluted with water
3. customThe precipitated solid is collected on
4. filtrationa filter
5. customrecrystallized from Skellysolve B