m-Chloroperbenzoic acid → 9,10-Epoxy-6,9,10-trimethyl-undec-5-en-2-one

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Reaction Steps

To a solution of 100 g. of 6,9,10-trimethyl-undeca-5,9-dien-2-one in 2,000 ml. of methylene chloride, there was added while cooling with ice, 100 g. of m-chloroperbenzoic acid. The resulting mixture was allowed to stand while constantly stirring at room temperature for 1 hour. The resulting mixture was diluted with 1,000 ml. of methylene chloride. The resulting solution was washed with ice-cold 1N sodium hydroxide solution and with a saturated sodium chloride solution, dried over sodium sulfate and evaporated. The residue was fractionally distilled under high vacuum. There was obtained 9,10-epoxy-6,9,10-trimethyl-undec-5-en-2-one; b.p. 89°-91°C./0.07 mmHg; nD20 = 1.4656.

Provenance & Evidence