Methanol → HCID 21534902, compound

HRID 1657585Notes

Reaction equation

HRID 1657585 reaction equation
[CH:1]1([CH:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:17])[NH:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CO>C(Cl)(Cl)Cl>[CH:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:17])[NH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 887MethanolHCID 21534894HCID 21534894, compound

Product 1

HCID 21534902HCID 21534902, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

50 g of 4-cyclohexyl-3,4-dihydro-2H-isoquinoline-1-one and 20 l g of methanol-wet 30% Pd/C were heated while to 220° C in a stream of argon. Thin-layer chromatographic analysis revealed that the reaction was practically completed after 75 minutes. The product was dissolved in chloroform, the catalyst was separated and the organic phase was evaporated. After recrystallization from acetone, colorless crystals were obtained. M.p. 111° to 112° C

Workup

  1. customthe catalyst was separated
  2. customthe organic phase was evaporated
  3. customAfter recrystallization from acetone
  4. customcolorless crystals were obtained

Sources & evidence

ORD record
ord-42d5da2834dc42539469445f7d68a375
Source dataset
uspto-grants-1976_06
Patent number
US03961062

Reaction notes

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