Dimethyl Sulfate → HCID 21534831, compound

HRID 1657593Notes

Reaction equation

HRID 1657593 reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][C:10]=3[S:16][CH3:17])[NH:5][C:4]=2[CH:3]=1.S(OC)(O[CH3:22])(=O)=O.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH3:22][O:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][C:10]=3[S:16][CH3:17])[NH:5][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 10340Sodium CarbonateHCID 21534841HCID 21534841, compound

Product 1

HCID 21534831HCID 21534831, compoundYield 50.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-Methoxy-6-methylthiophenothiazine (m.p. 152°-154°C.; 20.1 g.) is prepared by methylation of 2-hydroxy-6-methylthiophenothiazine (37.8 g.) by means of dimethyl sulphate (22.2 g.) in the presence of sodium carbonate (30.1 g.) in acetone.

Sources & evidence

ORD record
ord-f63d0ab4da8e4983ad1b4e10d78328ab
Source dataset
uspto-grants-1976_06
Patent number
US03961055

Reaction notes

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