Isopropyl iodide → 2-Isopropoxy-6-dimethylsulphamoylphenothiazine

HRID 1657599Notes

Reaction equation

I[CH:2]([CH3:4])[CH3:3].[OH:5][C:6]1[CH:19]=[CH:18][C:17]2[S:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[S:20](=[O:25])(=[O:24])[N:21]([CH3:23])[CH3:22])[NH:9][C:8]=2[CH:7]=1>>[CH:2]([O:5][C:6]1[CH:19]=[CH:18][C:17]2[S:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[S:20](=[O:25])(=[O:24])[N:21]([CH3:22])[CH3:23])[NH:9][C:8]=2[CH:7]=1)([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 215348332-Hydroxy-6-dimethylsulphamoylphenothiazine

Product 1

HCID 215348102-Isopropoxy-6-dimethylsulphamoylphenothiazineYield 94.6%

Procedure

2-Isopropoxy-6-dimethylsulphamoylphenothiazine (42.8 g.) is prepared by reacting 2-iodopropane (33.8 g.) with 2-hydroxy-6-dimethylsulphamoylphenothiazine (40.0 g.) prepared as indicated in Example 1.

Workup

customprepared

Sources & evidence

ORD record: ord-73887489799941459253b3d1621bbbb1
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03961055

Reaction notes

Loading…