4-Piperidineethanol → HCID 21534829, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-heptyloxy-6-dimethylsulphamoyl-10-(3-chloropropyl)phenothiazine (24.3 g.), 4-hydroxyethylpiperidine (7.1 g.) and sodium bicarbonate (16.1 g.) in dimethylformamide (180 cc.) is heated at about 130°C. for 8 hours with stirring. After cooling, the reaction mixture is evaporated to dryness under reduced pressure (15 mm.Hg) with heating to 65°C. The residue is taken up in distilled water (300 cc.) and then extracted with methylene chloride (total 560 cc.). The combined organic extracts are acidified by addition of a solution of methanesulphonic acid (57.6 cc.) in water (250 cc.). The organic phase is washed with an 8% aqueous solution of sodium hydroxide (total 300 cc.) and then with distilled water (total 1 litre), and is finally dried over sodium sulphate. On evaporation of the solvent under reduced pressure (15 mm. Hg) at 40°C., crude 2-heptyloxy-6-dimethylsulphamoyl-10-[3-(4-hydroxyethylpiperidino)propyl]-phenothiazine (21.1 g.), in the form of a brown viscous oil, is obtained.

Provenance & Evidence