HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)5H-[1]benzopyrano-[3,4-c]pyridin-5-one → 1,2,3,4-tetrahydro-8,9-dihydroxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)5H-[1]benzopyrano-[3,4-c]pyridin-5-one | HCID 21447171 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 1,2,3,4-tetrahydro-8,9-dihydroxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one | HCID 21447167 | 68.3% |
Reaction Steps
A solution of 8.7 g of 1,2,3,4-tetrahydro-8,9-dimethoxy-3-(2-morpholinoethyl)-5H[1]benzopyrano[3,4-c]pyridin-5-one in 60 cc of 48% HBr was refluxed for 17 hr then cooled. Crystallization of precipitate from water afforded 5.5 g of product; mp 299°-302°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03961057 |
| Source dataset | uspto-grants-1976_06 |
| ORD ID | ord-b3570c2776974885aebf00c625a7f094 |
| Source note | uspto-grants-1976_06 |