Dicyclohexylcarbodiimide → HCID 21433919, compound

HRID 1657644Notes

Reaction equation

HRID 1657644 reaction equation
[OH:1][C:2]1[C:7]2[C:8]3[CH2:16][CH2:15][S:14][C:9]=3[C:10]([CH3:13])([CH3:12])[O:11][C:6]=2[CH:5]=[C:4]([CH3:17])[CH:3]=1.[N:18]1([CH2:24][CH2:25][C:26](O)=[O:27])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.C1(N=C=NC2CCCCC2)CCCCC1>>[N:18]1([CH2:24][CH2:25][C:26]([O:1][C:2]2[C:7]3[C:8]4[CH2:16][CH2:15][S:14][C:9]=4[C:10]([CH3:12])([CH3:13])[O:11][C:6]=3[CH:5]=[C:4]([CH3:17])[CH:3]=2)=[O:27])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 1177821-Piperidinepropanoic acidHCID 21433908HCID 21433908, compound

Product 1

HCID 21433919HCID 21433919, compound

Procedure

Following a procedure similar to that described in Example 8 hereinabove, 1,2-dihydro-9-hydroxy-7-methyl-4-oxo-4H-thieno[2,3-c] [1]benzopyran is reacted with methyl magnesium bromide to give 1,2-dihydro-9-hydroxy-4,4,7-trimethyl-4H-thieno-[2,3-c] [1]benzopyran. The benzopyran is then reacted with β-piperidinopropionic acid and dicyclohexylcarbodiimide to yield the desired ester.

Sources & evidence

ORD record
ord-45955eee39ec49f885c292066af76feb
Source dataset
uspto-grants-1976_06
Patent number
US03960871

Reaction notes

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