Sodium Carbonate → L-Phenylalanine, methyl ester

HRID 1657689Notes

Reaction equation

HRID 1657689 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:14])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH2:6].C(=O)([O-])[O-].[Na+].[Na+]>O>[CH3:2][O:3][C:4](=[O:14])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[NH2:6]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 75736Methyl L-phenylalaninate hydrochloride

Product 1

HCID 736234L-Phenylalanine, methyl ester

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

241 g (1.1 Mole) L-phenylalanine methyl ester hydrochloride was dissolved in 900 ml water, and neutralized with 71 g sodium carbonate. The liberated L-phenylalanine methyl ester was extracted with 2.3 l ethyl acetate to give an L-phenylalanine methyl ester solution containing 1.05 mole of the ester which was mixed with 150 ml methanol.

Workup

  1. extractionThe liberated L-phenylalanine methyl ester was extracted with 2.3 l ethyl acetate

Sources & evidence

ORD record
ord-6bf0a7a7d1ab46a395cc807349f6a8e7
Source dataset
uspto-grants-1976_06
Patent number
US03962207

Reaction notes

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