Hydrochloric Acid → HCID 131710293, compound

Participants

Reaction Steps

3a,4,6,7-Tetrahydro-N,N-dimethyl-3-phenyl-7-(phenylmethylene)thiopyrano[4,3-c]pyrazole-2(3H)-propanamine-5,5-dioxide (3.4g) is dissolved in 25ml of warm methyl ethyl ketone, cooled and treated with 1.35ml of 6.1N alcoholic hydrogen chloride. On seeding and rubbing, the crystalline hydrogen chloride salt separates. Ether is added to complete the precipitation and after cooling for about 16 hours the solid is filtered, washed with ether and dried in vacuo to give 3.5g of material, melting point 183°-185°C. Following crystallization from 20ml of methanol-40ml of ether, there remains 2.6g of the title compound, melting point 192°-194°C.

Provenance & Evidence