Acetic Anhydride → 1-Nitro-1-(1,3-thiazinan-2-ylidene)propan-2-one

Participants

Reaction Steps

4.0 g of 2b was added in portions to 50 ml of acetic anhydride at 25°. The solution was heated at 95°-105° for 2 hours. Excess acetic anhydride was removed under reduced pressure to leave 5.0 g of a slightly gummy brown solid which was crystallized from ethyl acetate (after treatment with charcoal) to give 2 as a yellow-brown solid, m.p.: 110°-113°.

Provenance & Evidence