Sodium Carbonate → HCID 21530033, compound

HRID 1657702Notes

Reaction equation

HRID 1657702 reaction equation
Cl[C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH:8]([OH:13])[CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.BrC(C(=O)[C:23]1[CH:28]=[CH:27][C:26](Cl)=[CH:25][CH:24]=1)CC(O)=O.C(=O)([O-])[O-].[Na+].[Na+]>>[C:2]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:15]=[CH:14][C:5]([C:6]([CH:8]([OH:13])[CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 1696663-Bromo-4-(4-chlorophenyl)-4-oxobutanoic acidHCID 21530028HCID 21530028, compound

Product 1

HCID 21530033HCID 21530033, compound

Procedure

Groups R1 and R2 are defined above, are either known compounds (U.S. 3,714,218 and U.S. 3,749,750) or are prepared by techniques known to the chemist. For example, 3-(p-chlorobenzoyl)-3-hydroxy-propionic acid is prepared by reacting 3-bromo-3-(p-chlorobenzoyl)propionic acid with aqueous 10 percent sodium carbonate. The same displacement reaction yields 3-(4-biphenylylcarbonyl)-3-hydroxypropionic acid from the 3-bromoprecursor.

Workup

  1. customare prepared by techniques
  2. customThe same displacement reaction

Sources & evidence

ORD record
ord-43b42813775545bbabd061f5ba856f83
Source dataset
uspto-grants-1976_06
Patent number
US03962228

Reaction notes

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