Potassium Bromide → Benzhydryl 7-(2-thienylacetamido)-7-methoxy-3-acetoxymethyl-3-cephem-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

Manganese (III) acetate (5.0 g.) in acetic acid (60 ml.) is heated to 70°C. under nitrogen. To the stirred solution is added benzhydryl 7-(2-thienylacetamido)-7-methoxy-3-methyl-3-cephem-4-carboxylate (4.0 g.) and potassium bromide (0.5 g.). The solution is maintained at 70°C. for about eight hours. The reaction mixture is cooled and manganese (II) acetate is filtered from the cooled solution. The solvent is removed under vacuum to afford benzhydryl 7-(2-thienylacetamido)-7 -methoxy-3-acetoxymethyl-3-cephem-4-carboxylate.

Provenance & Evidence