HCID 131710304, compound → HCID 131710303, compound

Participants

Reaction Steps

A solution of 1.06 g of the ester of Step A in 10 ml of trifluoroacetic acid stood for 5 minutes and was then evaporated to dryness. The residue was taken up in benzene and evaporated to dryness. The residue was empasted with 20 ml of ether, stirred for 15 minutes, vacuum filtered, washed with ether and dried to obtain 790 mg of DL cis 7-p-nitrophenylacetamido-3-isopropyl-3-cepheme-4-carboxylic acid melting at 190°C with decomposition. The product occurred as colorless crystals slightly soluble in ethanol and insoluble in water.

Provenance & Evidence