反应详情

To a stirred solution of 7.2 g of 3-methylindole-1-ethanol, described in Example 1, in 500 ml. of dry ether (ice bath) is slowly added 1.2 ml of phosphorus tribromide in 100 ml of dry ether. A dark red oily complex separates. The eaction reaction is stirred 36-48 hours at room temperature, then decomposed with ice and water. The separated ether-layer is quickly washed with a 10% solution of sodium bicarbonate and with water again, dried over calcium chloride for 2 min., decanted, and dried over magnesium sulfate for 30 min. The filtrate is evaporated yielding 1-(2-bromoethyl)-3-methylindole.

1. customThe eaction reaction
2. washThe separated ether-layer is quickly washed with a 10% solution of sodium bicarbonate and with water again
3. dry with materialdried over calcium chloride for 2 min.
4. customdecanted
5. dry with materialdried over magnesium sulfate for 30 min
6. customThe filtrate is evaporated