Ammonia → HCID 12750590, compound

Participants

Reaction Steps

10.5 g of 2-(2-isocyanato-benzyl)-thiophene (B.P. 108°/0.05 mm of Hg) are heated to 110° with 105 g of polyphosphoric acid for 1 hour while stirring. The reaction mixture is subsequently rendered alkaline with a concentrated ammonia solution while cooling internally and externally with ice and the resulting precipitate is filtered off. This is washed with water, dried and crystallized from acetone while treating with charcoal. 4,5-dihydro-10H-thieno[3,2-c][1]benzazepin-4-one is obtained in the form of grains having a M.P. of 225°-236° (between 150° and 200° conversion into bright needles).

Provenance & Evidence