2-Furancarbonyl chloride → 1-(3-Phenylpropyl)-3-methyl-4-(2-furoyl)piperazine hydrochloride

HRID 1657759Notes

Reaction equation

HRID 1657759 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH:12]([CH3:16])[CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22]([Cl:24])=[O:23]>C1C=CC=CC=1>[ClH:24].[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:22]([C:18]3[O:17][CH:21]=[CH:20][CH:19]=3)=[O:23])[CH:12]([CH3:16])[CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 682422-Furancarbonyl chlorideHCID 215302811-(3-Phenylpropyl)-3-methylpiperazine

Product 1

HCID 215302691-(3-Phenylpropyl)-3-methyl-4-(2-furoyl)piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The compound was obtained by following the same process as in Example 2 from a mixture of 1-(3-phenylpropyl)-3-methylpiperazine [b.p. 120° - 125°C (3 mmHg), dipicrate, m.p. 249° - 250°C], 2-furoyl chloride and benzene.

Workup

  1. customThe compound was obtained

Sources & evidence

ORD record
ord-fddc94d72fa5497d90d1fb5601679b82
Source dataset
uspto-grants-1976_06
Patent number
US03962249

Reaction notes

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